Interaction of Cells with Nanomaterials

Principal Investigator

RNDr. Marie Kalbáčová, Ph.D.


Mgr. Antonín Brož, Mgr. Martina Verdánová, Blanka Bílková

Research field(s)

Biomaterials, biosensors, implant materials, mesenchymal stem cells

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Main results

Identification and characterization of influence of different surface nano-topographies and terminations on cell adhesion and proliferation

Kalbacova M,et al. Controlled oxygen plasma treatment of single-walled carbon nanotube films improves osteoblast cells attachment and enhances their proliferation, Carbon 2011; 49: 2926-2934, IF 4.504.

Kalbacova, et al. Graphene substrates promote adherence of human osteoblasts and mesenchymal stem cells, Carbon, 2010; 48: 4323-4329 IF 4.504

Kalbacova M, Nanoscale topography of nanocrystalline diamonds promotes differentiation of osteoblasts. Acta Biomat. 2009; 5: 3076-3085IF-3,975.

Kalbacova M, et al. Study on cellular adhesion of human osteoblasts on nano-structured diamond films, Phys Stat Sol, 2009; 246: 2774-2777 IF 1.15.

Identification and characterization of different materials used for biosensor development or medical treatment

Kalbacova M, et al., The effect of electrochemically stimulated titanium cathodic corrosion products on ROS production and metabolite activity of osteoblasts and monocytes/macrophages, Biomaterials, 2007, 28:3263-3272. IF 6.262.

Kalbacova M, et al., Influence of single-walled carbon nanotube films on metabolit aktivity and adherence of human osteoblasts, Carbon 2007, 45:2266-2272, IF 4.26.

Kalbacova M., et al., TiO2 nanotubes: Photocatalyst for cancer cell killing, Phys Stat Sol (RRL), 2008, 2:194-196, IF 2.147

Jin H, et al, Detection of single-molecular H2O2 signaling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes, Nature Nanotechnology 2010, 5:302-309, IF 30.306

Current & recent projects

Functional hybrid nanosystems of semiconductors and metals with organic materials (FUNS) is supported by the Grant agency of the Academy of Sciences of the Czech Republic in the framework program "Nanotechnology for Society".


Method of making arranged cell structures (EPO, PCT/CZ2009/000072)

Top-notch technologies available

Image analysis of pictures of cell structures (focal adhesions, organelles) obtained by confocal microscopy in real time